TRC210258, A NOVEL TGR5 AGONIST, REDUCES GLYCEMIC AND DYSLIPIDEMIC CARDIOVASCULAR RISK IN ANIMAL MODELS OF DIABESITY

TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity

Shitalkumar P Zambad, Davinder Tuli, Anoop Mathur, Sameer A Ghalsasi, Anita R Chaudhary, Shailesh Deshpande, Ramesh C Gupta, Vijay Chauthaiwale, Chaitanya DuttTorrent Research Centre, Torrent Pharmaceuticals Ltd, Gujarat, IndiaBackground: Patients with diabesity have a significantly increased risk of developing cardiovascular disease.Therefore

read more

Can loss of agency and oppositional perturbation associated with antidepressant monotherapy and low-fidelity psychological treatment dilute the benefits of guideline-consistent depression treatment at the population level?

Despite major expansions of evidence-based treatments of common mental disorders in recent decades, especially antidepressant medication, the point prevalence of depression has not decreased; instead it probably increased in young adults.We question whether antidepressants (AD)-monotherapy and low-fidelity-to-guideline psychological treatment (PT)

read more

Effect of built environment on tsunami related injuries

Background Built environment is a major determinant in injuries and deaths during natural disasters.Purpose of the present paper was to study the effect of built environment on tsunami injuries.Methods A retrospective residential cohort was constructed one month after the tsunami, based on the cross sectional household survey.Household structure Cu

read more

Heterophil/Lymphocyte Alterations as a Measure of Stress in American Alligators in Relation to Anthropogenic Disturbance in a Louisiana Intermediate Marsh

Numerous anthropogenic factors represent environmental threats to Gulf Coast wetland ecosystems and associated fauna.American alligators (Alligator mississippiensis) have been subject to long-term management and used as ecological and physiological indicators of habitat quality in response to anthropogenic events and stochastic natural disasters.Th

read more

Modern concept of biological identification of selenoproteins

Humans possess 25 selenoproteins, approximately half of which are enzymes (selenoenzymes) required for preventing, regulating, or reversing oxidative damage, while others participate in providing calcium metabolism, thyroid hormone maintenance, protein synthesis, cytoskeletal structure etc.This review examines the latest evidences of the biological

read more